Baclofen suppresses binge eating of pure fat but not a sugar-rich or sweet–fat diet
نویسندگان
چکیده
منابع مشابه
Baclofen for binge eating: an open-label trial.
OBJECTIVE Baclofen is a GABA-B agonist that may be useful in the treatment of substance use disorders, and also reduces 'binge-like' eating in rodents. We hypothesized that baclofen might be effective in reducing binge eating episodes in binge eating disorder (BED) and bulimia nervosa (BN). METHOD Seven women with BED (n = 4) or BN (n = 3) took baclofen (60 mg/day) for 10 weeks. RESULTS Six...
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Previous work from our laboratory indicates that when rats are given a choice between a high-fat and a high-sucrose diet, opioid blockade with naltrexone (NTX) in a reward-related site (central amygdala) inhibits intake of the preferred diet only, whereas NTX injected into a homeostasis-related site, such as the hypothalamic paraventricular nucleus (PVN), inhibits intake of both diets. However,...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2009
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e328331ba47